Publication Date:
2005-04-30
Description:
The design of a human immunodeficiency virus-1 (HIV-1) immunogen that can induce broadly reactive neutralizing antibodies is a major goal of HIV-1 vaccine development. Although rare human monoclonal antibodies (mAbs) exist that broadly neutralize HIV-1, HIV-1 envelope immunogens do not induce these antibody specificities. Here we demonstrate that the two most broadly reactive HIV-1 envelope gp41 human mAbs, 2F5 and 4E10, are polyspecific autoantibodies reactive with the phospholipid cardiolipin. Thus, current HIV-1 vaccines may not induce these types of antibodies because of autoantigen mimicry of the conserved membrane-proximal epitopes of the virus. These results may have important implications for generating effective neutralizing antibody responses by using HIV-1 vaccines.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Haynes, Barton F -- Fleming, Judith -- St Clair, E William -- Katinger, Herman -- Stiegler, Gabriela -- Kunert, Renate -- Robinson, James -- Scearce, Richard M -- Plonk, Kelly -- Staats, Herman F -- Ortel, Thomas L -- Liao, Hua-Xin -- Alam, S Munir -- AI51445/AI/NIAID NIH HHS/ -- P0-1 AI52816/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2005 Jun 24;308(5730):1906-8. Epub 2005 Apr 28.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Duke University School of Medicine, Durham, NC 27710, USA. hayne002@mc.duke.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15860590" target="_blank"〉PubMed〈/a〉
Keywords:
AIDS Vaccines/immunology
;
Animals
;
Antibodies, Monoclonal/*immunology
;
Antibody Specificity
;
Autoantibodies/chemistry/*immunology
;
Autoantigens/*immunology
;
Autoimmune Diseases/immunology
;
Cardiolipins/*immunology
;
Cell Line, Tumor
;
Epitopes
;
HIV Antibodies/chemistry/*immunology
;
HIV Envelope Protein gp41/chemistry/*immunology
;
HIV Infections/immunology
;
HIV-1/*immunology
;
Humans
;
Mice
;
Molecular Mimicry
;
Neutralization Tests
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
