Publication Date:
2005-08-16
Description:
Stem cells reside in specialized niches that provide signals required for their maintenance and division. Tissue-extrinsic signals can also modify stem cell activity, although this is poorly understood. Here, we report that neural-derived Drosophila insulin-like peptides (DILPs) directly regulate germline stem cell division rate, demonstrating that signals mediating the ovarian response to nutritional input can modify stem cell activity in a niche-independent manner. We also reveal a crucial direct role of DILPs in controlling germline cyst growth and vitellogenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉LaFever, Leesa -- Drummond-Barbosa, Daniela -- GM 069875/GM/NIGMS NIH HHS/ -- R01 GM069875/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2005 Aug 12;309(5737):1071-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell and Developmental Biology, Vanderbilt University Medical Center, 4120B Medical Research Building III, 465 21st Avenue South, Nashville, TN 37232-8240, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16099985" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cell Division
;
Cell Proliferation
;
Drosophila/cytology/genetics/*physiology
;
Drosophila Proteins/genetics/*physiology
;
Female
;
Food
;
Germ Cells/*cytology
;
Insulin/*physiology
;
Mutation
;
Ovarian Follicle/cytology/physiology
;
Ovary/cytology/physiology
;
Peptides/physiology
;
Receptor Protein-Tyrosine Kinases/genetics/physiology
;
*Signal Transduction
;
Stem Cells/*cytology
;
Vitellogenesis
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
