Publication Date:
2005-06-25
Description:
The orderly generation of cell types in the developing retina is thought to be regulated by changes in the competence of multipotent progenitors. Here, we show that a secreted factor, growth and differentiation factor 11 (GDF11), controls the numbers of retinal ganglion cells (RGCs), as well as amacrine and photoreceptor cells, that form during development. GDF11 does not affect proliferation of progenitors-a major mode of GDF11 action in other tissues-but instead controls duration of expression of Math5, a gene that confers competence for RGC genesis, in progenitor cells. Thus, GDF11 governs the temporal windows during which multipotent progenitors retain competence to produce distinct neural progeny.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kim, Joon -- Wu, Hsiao-Huei -- Lander, Arthur D -- Lyons, Karen M -- Matzuk, Martin M -- Calof, Anne L -- AR44528/AR/NIAMS NIH HHS/ -- DC03583/DC/NIDCD NIH HHS/ -- HD32067/HD/NICHD NIH HHS/ -- HD38761/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 2005 Jun 24;308(5730):1927-30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Anatomy and Neurobiology, University of California, Irvine, CA 92697, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15976303" target="_blank"〉PubMed〈/a〉
Keywords:
Amacrine Cells/*cytology
;
Animals
;
Basic Helix-Loop-Helix Transcription Factors
;
Bone Morphogenetic Proteins/genetics/*physiology
;
Cell Count
;
Cell Differentiation
;
Cell Proliferation
;
DNA-Binding Proteins/genetics/metabolism
;
Feedback, Physiological
;
Gene Expression Regulation, Developmental
;
Growth Differentiation Factors
;
Mice
;
Mice, Inbred C57BL
;
Multipotent Stem Cells/cytology/*physiology
;
Mutation
;
Nerve Tissue Proteins/genetics/metabolism/physiology
;
Retina/*cytology/*embryology
;
Retinal Ganglion Cells/*cytology
;
Retinal Rod Photoreceptor Cells/*cytology/embryology
;
Transcription Factors/genetics/metabolism/physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
