Publication Date:
2005-02-12
Description:
We compared fine-scale recombination rates at orthologous loci in humans and chimpanzees by analyzing polymorphism data in both species. Strong statistical evidence for hotspots of recombination was obtained in both species. Despite approximately 99% identity at the level of DNA sequence, however, recombination hotspots were found rarely (if at all) at the same positions in the two species, and no correlation was observed in estimates of fine-scale recombination rates. Thus, local patterns of recombination rate have evolved rapidly, in a manner disproportionate to the change in DNA sequence.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Winckler, Wendy -- Myers, Simon R -- Richter, Daniel J -- Onofrio, Robert C -- McDonald, Gavin J -- Bontrop, Ronald E -- McVean, Gilean A T -- Gabriel, Stacey B -- Reich, David -- Donnelly, Peter -- Altshuler, David -- New York, N.Y. -- Science. 2005 Apr 1;308(5718):107-11. Epub 2005 Feb 10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biology and Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114-2622, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15705809" target="_blank"〉PubMed〈/a〉
Keywords:
Alleles
;
Animals
;
Base Sequence
;
Chromosome Mapping
;
Chromosomes, Human/genetics
;
Chromosomes, Mammalian/genetics
;
Evolution, Molecular
;
*Genome
;
*Genome, Human
;
Genotype
;
Globins/genetics
;
HLA Antigens/genetics
;
Haplotypes
;
Humans
;
Linkage Disequilibrium
;
Markov Chains
;
Monte Carlo Method
;
Pan troglodytes/*genetics
;
Polymorphism, Single Nucleotide
;
*Recombination, Genetic
;
Sequence Homology, Nucleic Acid
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
