Publication Date:
2005-01-18
Description:
Dendritic cells (DCs) and macrophages are critical to innate and adaptive immunity to the intestinal bacterial microbiota. Here, we identify a myeloid-derived mucosal DC in mice, which populates the entire lamina propria of the small intestine. Lamina propria DCs were found to depend on the chemokine receptor CX3CR1 to form transepithelial dendrites, which enable the cells to directly sample luminal antigens. CX3CR1 was also found to control the clearance of entero-invasive pathogens by DCs. Thus, CX3CR1-dependent processes, which control host interactions of specialized DCs with commensal and pathogenic bacteria, may regulate immunological tolerance and inflammation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Niess, Jan Hendrik -- Brand, Stephan -- Gu, Xiubin -- Landsman, Limor -- Jung, Steffen -- McCormick, Beth A -- Vyas, Jatin M -- Boes, Marianne -- Ploegh, Hidde L -- Fox, James G -- Littman, Dan R -- Reinecker, Hans-Christian -- AI33856/AI/NIAID NIH HHS/ -- DK33506/DK/NIDDK NIH HHS/ -- DK54427/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2005 Jan 14;307(5707):254-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15653504" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Chemokine CX3CL1
;
Chemokines, CX3C/metabolism
;
Dendritic Cells/cytology/*immunology/microbiology
;
Escherichia coli/*immunology/isolation & purification
;
Gene Deletion
;
Green Fluorescent Proteins/metabolism
;
Ileum/cytology/immunology
;
*Immunity, Mucosal
;
Intestinal Mucosa/*immunology/microbiology
;
Intestine, Small/immunology/microbiology
;
Lymphoid Tissue/cytology/immunology
;
Membrane Proteins/metabolism
;
Mice
;
Mice, Transgenic
;
Peyer's Patches/immunology/microbiology
;
Phagocytosis
;
Receptors, Chemokine/genetics/metabolism/*physiology
;
Salmonella Infections, Animal/*immunology/microbiology
;
Salmonella typhimurium/*immunology/isolation & purification
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
