Publication Date:
2004-12-14
Description:
To establish infection in the host, malaria parasites export remodeling and virulence proteins into the erythrocyte. These proteins can traverse a series of membranes, including the parasite membrane, the parasitophorous vacuole membrane, and the erythrocyte membrane. We show that a conserved pentameric sequence plays a central role in protein export into the host cell and predict the exported proteome in Plasmodium falciparum. We identified 400 putative erythrocyte-targeted proteins corresponding to approximately 8% of all predicted genes, with 225 virulence proteins and a further 160 proteins likely to be involved in remodeling of the host erythrocyte. The conservation of this signal across Plasmodium species has implications for the development of new antimalarials.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marti, Matthias -- Good, Robert T -- Rug, Melanie -- Knuepfer, Ellen -- Cowman, Alan F -- R01-A144008-04A1/PHS HHS/ -- New York, N.Y. -- Science. 2004 Dec 10;306(5703):1930-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3050, Australia.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15591202" target="_blank"〉PubMed〈/a〉
Keywords:
*Amino Acid Motifs
;
Amino Acid Sequence
;
Animals
;
Computational Biology
;
Cytoplasm/metabolism
;
Erythrocyte Membrane/metabolism
;
Gene Expression Profiling
;
Genes, Protozoan
;
Humans
;
Hydrophobic and Hydrophilic Interactions
;
Malaria, Falciparum/parasitology
;
Membrane Proteins/chemistry/metabolism
;
Molecular Sequence Data
;
Oligonucleotide Array Sequence Analysis
;
Plasmodium/chemistry/genetics/metabolism
;
Plasmodium falciparum/genetics/growth & development/*metabolism/*pathogenicity
;
*Protein Sorting Signals
;
Protein Transport
;
Protozoan Proteins/chemistry/genetics/*metabolism
;
Recombinant Fusion Proteins/metabolism
;
Sequence Alignment
;
Vacuoles/metabolism/parasitology
;
Virulence
;
Virulence Factors/chemistry/genetics/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
