Publication Date:
2004-04-10
Description:
The idea that new memories undergo a time-dependent consolidation process after acquisition has received considerable experimental support. More controversial has been the demonstration that established memories, once recalled, become labile and sensitive to disruption, requiring "reconsolidation" to become permanent. By infusing antisense oligodeoxynucleotides into the hippocampus of rats, we show that consolidation and reconsolidation are doubly dissociable component processes of memory. Consolidation involves brain-derived neurotrophic factor (BDNF) but not the transcription factor Zif268, whereas reconsolidation recruits Zif268 but not BDNF. These findings confirm a requirement for BDNF specifically in memory consolidation and also resolve the role of Zif268 in brain plasticity, learning, and memory.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lee, Jonathan L C -- Everitt, Barry J -- Thomas, Kerrie L -- G9537855/Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2004 May 7;304(5672):839-43. Epub 2004 Apr 8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15073322" target="_blank"〉PubMed〈/a〉
Keywords:
Amnesia/physiopathology
;
Animals
;
Brain-Derived Neurotrophic Factor/administration &
;
dosage/genetics/metabolism/pharmacology/*physiology
;
Conditioning (Psychology)
;
Cytoskeletal Proteins
;
Dentate Gyrus/metabolism/physiology
;
*Fear
;
Hippocampus/metabolism/*physiology
;
Immediate-Early Proteins/metabolism
;
Memory/*physiology
;
Mental Recall/physiology
;
*Nerve Tissue Proteins
;
Neuronal Plasticity
;
Oligonucleotides, Antisense/administration & dosage/pharmacology
;
Rats
;
Recombinant Proteins/administration & dosage/pharmacology
;
Signal Transduction
;
Time Factors
;
Transcription, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
