Publication Date:
2004-04-24
Description:
Memory T cells are long-lived antigen-experienced T cells that are generally accepted to be direct descendants of proliferating primary effector cells. However, the factors that permit selective survival of these T cells are not well established. We show that homodimeric alpha chains of the CD8 molecule (CD8alphaalpha) are transiently induced on a selected subset of CD8alphabeta+ T cells upon antigenic stimulation. These CD8alphaalpha molecules promote the survival and differentiation of activated lymphocytes into memory CD8 T cells. Thus, memory precursors can be identified among primary effector cells and are selected for survival and differentiation by CD8alphaalpha.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Madakamutil, Loui T -- Christen, Urs -- Lena, Christopher J -- Wang-Zhu, Yiran -- Attinger, Antoine -- Sundarrajan, Monisha -- Ellmeier, Wilfried -- von Herrath, Matthias G -- Jensen, Peter -- Littman, Dan R -- Cheroutre, Hilde -- AI33614/AI/NIAID NIH HHS/ -- AI50263/AI/NIAID NIH HHS/ -- AI51973/AI/NIAID NIH HHS/ -- DK54451/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2004 Apr 23;304(5670):590-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15105501" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antigen-Presenting Cells/immunology
;
Antigens, CD8/*immunology
;
Arenaviridae Infections/immunology
;
CD8-Positive T-Lymphocytes/*immunology
;
Cell Differentiation
;
Cell Survival
;
*Immunologic Memory
;
Interferon-gamma/biosynthesis
;
*Lymphocyte Activation
;
Lymphocytic choriomeningitis virus/immunology
;
Membrane Glycoproteins/immunology/metabolism
;
Mice
;
Mice, Inbred C57BL
;
Mice, Knockout
;
Mice, Transgenic
;
Receptors, Interleukin-7/immunology/metabolism
;
T-Lymphocyte Subsets/immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
