Publication Date:
2002-12-10
Description:
Polarized cell movements shape the major features of the vertebrate body plan during development. The head-to-tail body axis of vertebrates is elongated in embryonic stages by "convergent extension" tissue movements. During these movements cells intercalate between one another transverse to the elongating body axis to form a narrower, longer array. Recent discoveries show that these polarized cell movements are controlled by homologs of genes that control the polarity of epithelial cells in the developing wing and eye of the fruit fly, Drosophila.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Keller, Ray -- New York, N.Y. -- Science. 2002 Dec 6;298(5600):1950-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, University of Virginia, Charlottesville, VA 22904, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12471247" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
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*Body Patterning
;
*Cell Movement
;
*Cell Polarity
;
Cell Size
;
Drosophila/cytology/genetics/growth & development
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Embryo, Mammalian/*cytology/physiology
;
Embryo, Nonmammalian/*cytology/physiology
;
Embryonic Development
;
Embryonic and Fetal Development
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Gene Expression Regulation, Developmental
;
Genes
;
Morphogenesis
;
Proteins/metabolism
;
Signal Transduction
;
Vertebrates/*embryology/genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
