Publication Date:
2002-06-22
Description:
The recently developed testis cell transplantation method provides a powerful approach to studying the biology of the male germline stem cell and its microenvironment, the stem cell niche. The technique also is being used to examine spermatogenic defects, correct male infertility, and generate transgenic animals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brinster, Ralph L -- 36504/PHS HHS/ -- New York, N.Y. -- Science. 2002 Jun 21;296(5576):2174-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, 3850 Baltimore Avenue, Philadelphia, PA 19104, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12077400" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cell Differentiation
;
Cell Separation
;
Cells, Cultured
;
Cryopreservation
;
Humans
;
Male
;
Seminiferous Tubules/cytology
;
Sertoli Cells/physiology
;
*Spermatogenesis
;
Spermatogonia/*cytology/physiology
;
*Stem Cell Transplantation
;
Stem Cells/physiology
;
Testis/*cytology
;
Transduction, Genetic
;
*Transgenes
;
Transplantation, Heterologous
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
