Publication Date:
2002-05-23
Description:
RNA silencing is a sequence-specific RNA degradation mechanism that is operational in plants and animals. Here, we show that flock house virus (FHV) is both an initiator and a target of RNA silencing in Drosophila host cells and that FHV infection requires suppression of RNA silencing by an FHV-encoded protein, B2. These findings establish RNA silencing as an adaptive antiviral defense in animal cells. B2 also inhibits RNA silencing in transgenic plants, providing evidence for a conserved RNA silencing pathway in the plant and animal kingdoms.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Li, Hongwei -- Li, Wan Xiang -- Ding, Shou Wei -- New York, N.Y. -- Science. 2002 May 17;296(5571):1319-21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Plant Pathology and Center for Plant Cell Biology, University of California, Riverside, CA 92521, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12016316" target="_blank"〉PubMed〈/a〉
Keywords:
Agrobacterium tumefaciens/genetics
;
Animals
;
Cell Line
;
Drosophila/genetics/*virology
;
*Gene Silencing
;
Genes, Viral
;
Green Fluorescent Proteins
;
Luminescent Proteins/genetics
;
Nodaviridae/*genetics/*physiology
;
Plant Leaves/genetics/metabolism
;
Plants, Genetically Modified
;
RNA, Double-Stranded/genetics/metabolism
;
RNA, Small Interfering
;
RNA, Untranslated/*metabolism
;
RNA, Viral/genetics/metabolism
;
Tobacco/*genetics/metabolism/microbiology
;
Transfection
;
Viral Proteins/genetics/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
