Publication Date:
2002-05-11
Description:
The bacterium Wolbachia manipulates reproduction in millions of insects worldwide; the most common effect is cytoplasmic incompatibility (CI). We found that CI resulted from delayed nuclear envelope breakdown of the male pronucleus in Nasonia vitripennis. This caused asynchrony between the male and female pronuclei and, ultimately, loss of paternal chromosomes at the first mitosis. When Wolbachia were present in the egg, synchrony was restored, which explains suppression of CI in these crosses. These results suggest that Wolbachia target cell cycle regulatory proteins. A striking consequence of CI is that it alters the normal pattern of reciprocal centrosome inheritance in Nasonia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tram, Uyen -- Sullivan, William -- GM16409/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2002 May 10;296(5570):1124-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular, Cell, and Developmental Biology, 319 Sinsheimer Labs, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12004132" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
CDC2 Protein Kinase/metabolism
;
Centrosome/physiology
;
Chromosomes/physiology
;
Cytoplasm/physiology
;
Embryo, Nonmammalian/physiology
;
Female
;
Fertilization
;
Histones/metabolism
;
Male
;
*Mitosis
;
Motion Pictures as Topic
;
Nuclear Envelope/*physiology
;
Ovum/microbiology/physiology
;
Phosphorylation
;
Spermatozoa/microbiology/physiology
;
Spindle Apparatus/physiology
;
Time Factors
;
Wasps/embryology/*microbiology/*physiology
;
Wolbachia/*physiology
;
Zygote/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
