Publication Date:
2002-03-16
Description:
Natural killer cell (NK) receptors for major histocompatibility complex (MHC) class I influence engraftment and graft-versus-tumor effects after allogeneic bone marrow transplantation. We find that SH2-containing inositol phosphatase (SHIP) influences the repertoire of NK receptors. In adult SHIP-/- mice, the NK compartment is dominated by cells that express two inhibitory receptors capable of binding either self or allogeneic MHC ligands. This promiscuous repertoire has significant functional consequences, because SHIP-/- mice fail to reject fully mismatched allogeneic marrow grafts and show enhanced survival after such transplants. Thus, SHIP plays an important role in two processes that limit the success of allogeneic marrow transplantation: graft rejection and graft-versus-host disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wang, Jia-Wang -- Howson, Julie M -- Ghansah, Tomar -- Desponts, Caroline -- Ninos, John M -- May, Sarah L -- Nguyen, Kim H T -- Toyama-Sorimachi, Noriko -- Kerr, William G -- P01 NS27405/NS/NINDS NIH HHS/ -- R01 DK54767/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2002 Mar 15;295(5562):2094-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Immunology Program, H. Lee Moffitt Comprehensive Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11896280" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antigens, CD/metabolism
;
*Antigens, Ly
;
Bone Marrow Transplantation/*immunology
;
Cell Survival
;
Graft Rejection/*immunology
;
Graft Survival
;
Graft vs Host Disease/*immunology
;
H-2 Antigens/immunology/metabolism
;
Haplotypes
;
Histocompatibility Antigens Class I/immunology/metabolism
;
Killer Cells, Natural/enzymology/*immunology/metabolism
;
*Lectins, C-Type
;
Ligands
;
Lymphocyte Count
;
Lymphocyte Subsets/immunology/metabolism
;
Membrane Glycoproteins/metabolism
;
Mice
;
Mice, Inbred A
;
Mice, Inbred BALB C
;
NK Cell Lectin-Like Receptor Subfamily D
;
Phosphatidylinositol 3-Kinases/metabolism
;
Phosphoric Monoester Hydrolases/chemistry/genetics/*metabolism
;
Phosphorylation
;
*Protein-Serine-Threonine Kinases
;
Proto-Oncogene Proteins/metabolism
;
Proto-Oncogene Proteins c-akt
;
Receptors, Immunologic/metabolism
;
Receptors, NK Cell Lectin-Like
;
Signal Transduction
;
Transplantation, Homologous
;
src Homology Domains
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
