Publication Date:
2002-01-12
Description:
T-bet is a member of the T-box family of transcription factors that appears to regulate lineage commitment in CD4 T helper (TH) lymphocytes in part by activating the hallmark TH1 cytokine, interferon-gamma (IFN-gamma). IFN-gamma is also produced by natural killer (NK) cells and most prominently by CD8 cytotoxic T cells, and is vital for the control of microbial pathogens. Although T-bet is expressed in all these cell types, it is required for control of IFN-gamma production in CD4 and NK cells, but not in CD8 cells. This difference is also apparent in the function of these cell subsets. Thus, the regulation of a single cytokine, IFN-gamma, is controlled by distinct transcriptional mechanisms within the T cell lineage.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Szabo, Susanne J -- Sullivan, Brandon M -- Stemmann, Claudia -- Satoskar, Abhay R -- Sleckman, Barry P -- Glimcher, Laurie H -- New York, N.Y. -- Science. 2002 Jan 11;295(5553):338-42.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11786644" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
CD4-Positive T-Lymphocytes/*immunology/physiology
;
Cell Differentiation
;
Cell Line
;
Cell Lineage
;
Cytotoxicity, Immunologic
;
Gene Targeting
;
Immunization
;
Immunoglobulin G/biosynthesis
;
Interferon-gamma/*biosynthesis
;
Interleukin-4/biosynthesis
;
Interleukin-5/biosynthesis
;
Killer Cells, Natural/immunology/metabolism
;
Leishmania major
;
Leishmaniasis, Cutaneous/immunology
;
Mice
;
Mice, Inbred BALB C
;
Mice, Inbred C57BL
;
T-Box Domain Proteins
;
T-Lymphocytes, Cytotoxic/*immunology
;
Th1 Cells/*immunology
;
Transcription Factors/deficiency/*genetics/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
