Publication Date:
2001-05-26
Description:
Adenosine triphosphate (ATP)-sensitive potassium (K(ATP)) channels are activated by various metabolic stresses, including hypoxia. The substantia nigra pars reticulata (SNr), the area with the highest expression of K(ATP) channels in the brain, plays a pivotal role in the control of seizures. Mutant mice lacking the Kir6.2 subunit of K(ATP) channels [knockout (KO) mice] were susceptible to generalized seizures after brief hypoxia. In normal mice, SNr neuron activity was inactivated during hypoxia by the opening of the postsynaptic K(ATP) channels, whereas in KO mice, the activity of these neurons was enhanced. K(ATP) channels exert a depressant effect on SNr neuronal activity during hypoxia and may be involved in the nigral protection mechanism against generalized seizures.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yamada, K -- Ji, J J -- Yuan, H -- Miki, T -- Sato, S -- Horimoto, N -- Shimizu, T -- Seino, S -- Inagaki, N -- New York, N.Y. -- Science. 2001 May 25;292(5521):1543-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology, Akita University School of Medicine, Hondo, Akita 010-8543, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11375491" target="_blank"〉PubMed〈/a〉
Keywords:
Adenosine Triphosphate/*metabolism/pharmacology
;
Animals
;
Anoxia/*physiopathology
;
Electroencephalography
;
Electromyography
;
Excitatory Amino Acid Antagonists/pharmacology
;
In Vitro Techniques
;
Male
;
Membrane Potentials
;
Mice
;
Mice, Knockout
;
Neurons/*physiology
;
Patch-Clamp Techniques
;
Potassium Channels/genetics/*physiology
;
*Potassium Channels, Inwardly Rectifying
;
Seizures/*physiopathology/prevention & control
;
Substantia Nigra/*physiology/physiopathology
;
Synaptic Transmission/drug effects
;
gamma-Aminobutyric Acid/physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
