Publication Date:
2001-07-07
Description:
Amyloid-beta precursor protein (APP), a widely expressed cell-surface protein, is cleaved in the transmembrane region by gamma-secretase. gamma-Cleavage of APP produces the extracellular amyloid beta-peptide of Alzheimer's disease and releases an intracellular tail fragment of unknown physiological function. We now demonstrate that the cytoplasmic tail of APP forms a multimeric complex with the nuclear adaptor protein Fe65 and the histone acetyltransferase Tip60. This complex potently stimulates transcription via heterologous Gal4- or LexA-DNA binding domains, suggesting that release of the cytoplasmic tail of APP by gamma-cleavage may function in gene expression.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cao, X -- Sudhof, T C -- New York, N.Y. -- Science. 2001 Jul 6;293(5527):115-20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, TX 75390-9111 USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11441186" target="_blank"〉PubMed〈/a〉
Keywords:
Acetyltransferases/chemistry/genetics/*metabolism
;
Amyloid Precursor Protein Secretases
;
Amyloid beta-Protein Precursor/*chemistry/genetics/*metabolism
;
Animals
;
Aspartic Acid Endopeptidases
;
Bacterial Proteins/genetics/metabolism
;
Cell Line
;
DNA-Binding Proteins/chemistry/genetics/metabolism
;
Endopeptidases/metabolism
;
Fungal Proteins/genetics/metabolism
;
Histone Acetyltransferases
;
Humans
;
Macromolecular Substances
;
Mutation/genetics
;
Nerve Tissue Proteins/chemistry/genetics/*metabolism
;
Nuclear Proteins/chemistry/genetics/*metabolism
;
Peptide Fragments/chemistry/genetics/metabolism
;
Plasmids/genetics
;
Precipitin Tests
;
Protein Binding
;
Protein Processing, Post-Translational
;
Protein Structure, Tertiary
;
Protein Transport
;
Rats
;
Recombinant Fusion Proteins/chemistry/genetics/metabolism
;
*Saccharomyces cerevisiae Proteins
;
Serine Endopeptidases/genetics/metabolism
;
Transcription Factors/genetics/metabolism
;
*Transcription, Genetic
;
Transcriptional Activation
;
Transfection
;
Two-Hybrid System Techniques
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
