Publication Date:
2018-11-16
Description:
Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis, Published online: 15 November 2018; doi:10.1038/s41467-018-07213-x CD8 T cells can protect the liver from viral infection, but can also result in severe liver damage and organ failure. Here, the authors develop a mouse model reflecting fulminant CD8 T cell mediated viral hepatitis, which occurs in a perforin-dependent manner that is protected by the use of perforin inhibitors.
Electronic ISSN:
2041-1723
Topics:
Biology
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Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics