Publication Date:
2018-02-08
Description:
A small molecule inhibitor of Rheb selectively targets mTORC1 signaling A small molecule inhibitor of Rheb selectively targets mTORC1 signaling, Published online: 07 February 2018; doi:10.1038/s41467-018-03035-z Aberrant mTORC1 signaling is linked to several chronic diseases. Here, the authors develop a small molecule inhibitor that binds the small G-protein Rheb and selectively blocks mTORC1 signaling, holding potential for therapeutic applications.
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics