Publication Date:
2017-08-25
Description:
An integrated bioinformatics platform for investigating the human E3 ubiquitin ligase-substrate interaction network Nature Communications, Published online: 24 August 2017; doi:10.1038/s41467-017-00299-9 Protein stability modulation by E3 ubiquitin ligases is an important layer of functional regulation, but screening for E3 ligase-substrate interactions is time-consuming and costly. Here, the authors take an in silico naïve Bayesian classifier approach to integrate multiple lines of evidence for E3-substrate prediction, enabling prediction of the proteome-wide human E3 ligase interaction network.
Electronic ISSN:
2041-1723
Topics:
Biology
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Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics