Publication Date:
2016-06-25
Description:
Article miR125b-5p has been associated with acute liver failure. Here the authors show that this miRNA targets Keap1 and activates Nrf2 to inhibit liver cell death after APAP or FAS toxicity, plus they show that a miR125b-5p mimic can inhibit ALF in mice. Nature Communications doi: 10.1038/ncomms11916 Authors: Dakai Yang, Qinggong Yuan, Asha Balakrishnan, Heike Bantel, Jan-Henning Klusmann, Michael P. Manns, Michael Ott, Tobias Cantz, Amar Deep Sharma
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics