Publication Date:
2016-01-14
Description:
Nineteen compounds mainly including pyrrole-containing alkaloids and phytosterols were isolated from the EtOH extract of the fermented mycelia of Xylaria nigripes , a precious medicinal fungus known as Wuling Shen in Chinese. On the basis of spectroscopic methods, the structures of the new naturally occurring compounds were determined to be (4 S )-3,4-dihydro-4-(4-hydroxybenzyl)-3-oxo-1 H -pyrrolo[2,1- c ][1,4]oxazine-6-carbaldehyde ( 1 ), methyl (2 S )-2-[2-formyl-5-(hydroxymethyl)-1 H -pyrrol-1-yl]-3-(4-hydroxyphenyl)propanoate ( 2 ), and 3-{4-[(2 R )-(2,3-dihydroxy-3-methylbutoxy]phenyl}-7-hydroxy-4 H -chromen-4-one ( 3 ), respectively. The absolute configurations of 1 and 2 were deduced by the observed Cotton effects in their circular dichroism (CD) spectra, whereas that of the 1,2-diol moiety in 3 was determined using the Snatzke 's method. Their biological activities such as neuroprotective, anti-neuroinflammatory, and cytotoxic properties were also reported.
Print ISSN:
0018-019X
Electronic ISSN:
1522-2675
Topics:
Chemistry and Pharmacology
