Publication Date:
2015-12-20
Description:
Article Cyclotides are plant backbone-cyclised peptides with potential as pharmaceutical scaffolds. Here the authors report on the efficient backbone cyclization of cyclotides and unrelated peptides by a newly identified asparaginyl endopeptidase from Oldenlandia affinis . Nature Communications doi: 10.1038/ncomms10199 Authors: Karen S. Harris, Thomas Durek, Quentin Kaas, Aaron G. Poth, Edward K. Gilding, Brendon F. Conlan, Ivana Saska, Norelle L. Daly, Nicole L. van der Weerden, David J. Craik, Marilyn A. Anderson
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics