Publication Date:
2015-04-19
Description:
Article After activation and selection, plasma cells home to the bone marrow where they persist and continue to make antibodies. Here the authors show that the mir-17–92 cluster coordinates the process by regulating the homing receptor S1PR1 and the transcription factor IKAROS that controls IgG2c production. Nature Communications doi: 10.1038/ncomms7764 Authors: Shengli Xu, Xijun Ou, Jianxin Huo, Kristen Lim, Yuhan Huang, Sheena Chee, Kong-Peng Lam
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics