Publication Date:
2015-01-22
Description:
Article Protein tyrosine kinases are subject to multiple regulatory mechanisms. Foda et al . show that reactants and products of the tyrosine kinase Src bind its catalytic domain with opposite cooperativity, and identify an allosteric network of dynamically coupled amino acids that underlie this behaviour. Nature Communications doi: 10.1038/ncomms6939 Authors: Zachariah H. Foda, Yibing Shan, Eric T. Kim, David E. Shaw, Markus A. Seeliger
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics