Publication Date:
2014-12-17
Description:
Article Epidermal growth factor receptor (EGFR) elicits the signalling function after dimerization and activation of its kinase activity and perturbations in this pathway are often found in cancer. Here the authors describe two distinct and mutually exclusive modes of EGFR signalling due to a switch of EGFR-associated proteins with the ligand. Nature Communications doi: 10.1038/ncomms6811 Authors: Sharmistha Chakraborty, Li Li, Vineshkumar Thidil Puliyappadamba, Gao Guo, Kimmo J. Hatanpaa, Bruce Mickey, Rhonda F. Souza, Peggy Vo, Joachim Herz, Mei-Ru Chen, David A. Boothman, Tej K. Pandita, David H. Wang, Ganes C. Sen, Amyn A. Habib
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics