Publication Date:
2019
Description:
〈p〉Publication date: October 2019〈/p〉
〈p〉〈b〉Source:〈/b〉 Fish & Shellfish Immunology, Volume 93〈/p〉
〈p〉Author(s): Tetsuro Ikuta, Akihiro Tame, Masaki Saito, Yui Aoki, Yukiko Nagai, Makoto Sugimura, Koji Inoue, Katsunori Fujikura, Kazue Ohishi, Tadashi Maruyama, Takao Yoshida〈/p〉
〈div xml:lang="en"〉
〈h5〉Abstract〈/h5〉
〈div〉〈p〉In symbiotic systems in which symbionts are transmitted horizontally, hosts must accept symbionts from the environment while defending themselves against invading pathogenic microorganisms. How they distinguish pathogens from symbionts and how the latter evade host immune defences are not clearly understood. Recognition of foreign materials is one of the most critical steps in stimulating immune responses, and pattern recognition receptors (PRRs) play vital roles in this process. In this study, we focused on a group of highly conserved PRRs, peptidoglycan recognition proteins (PGRPs), in the deep-sea mussel, 〈em〉Bathymodiolus septemdierum〈/em〉, which harbours chemosynthetic bacteria in their gill epithelial cells. We isolated 〈em〉B. septemdierum〈/em〉 PGRP genes 〈em〉BsPGRP-S〈/em〉 and 〈em〉BsPGRP-L〈/em〉, which encode a short- and a long-type PGRP, respectively. The short-type PGRP has a signal peptide and was expressed in the asymbiotic goblet mucous cells in the gill epithelium, whereas the long-type PGRP was predicted to include a transmembrane domain and was expressed in gill bacteriocytes. Based on these findings, we hypothesize that the secreted and transmembrane PGRPs are engaged in host defence against pathogenic bacteria and/or in the regulation of symbiosis via different cellular localizations and mechanisms.〈/p〉〈/div〉
〈/div〉
Print ISSN:
1050-4648
Electronic ISSN:
1095-9947
Topics:
Biology
,
Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
,
Medicine
