Publication Date:
2019
Description:
〈p〉The notable male predominance across many human cancer types remains unexplained. Here, we show that 〈i〉Drosophila〈/i〉 l(3)mbt brain tumors are more invasive and develop as malignant neoplasms more often in males than in females. By quantitative proteomics, we have identified a signature of proteins that are differentially expressed between male and female tumor samples. Prominent among them is the conserved chromatin reader PHD finger protein 7 (Phf7). We show that 〈i〉Phf7〈/i〉 depletion reduces sex-dependent differences in gene expression and suppresses the enhanced malignant traits of male tumors. Our results identify potential regulators of sex-linked tumor dimorphism and show that these genes may serve as targets to suppress sex-linked malignant traits.〈/p〉
Electronic ISSN:
2375-2548
Topics:
Natural Sciences in General