Publikationsdatum:
2019
Beschreibung:
〈h3〉Abstract〈/h3〉
〈p〉Endophytic fungi live inside vegetal tissues without causing damage to the host plant and may provide lead compounds for drug discovery. The co-culture of two or more endophytic fungi can trigger silent gene clusters, which could lead to the isolation of bioactive compounds. In this study, two endophytic strains isolated from 〈em〉Handroanthus impetiginosus〈/em〉 leaves, identified as 〈em〉Talaromyces purpurogenus〈/em〉 H4 and 〈em〉Phanerochaete〈/em〉 sp. H2, were grown in mixed and axenic cultures. The meroterpenoid austin was detected only in the extracts from the mixed culture. Once isolated, austin displayed very interesting trypanocidal activity, with an IC〈sub〉50〈/sub〉 value of 36.6 ± 1.2 μg/mL against 〈em〉Trypanosoma cruzi〈/em〉 in the epimastigote form. The results obtained highlight the importance of the co-culturing of endophytic fungi to obtain natural bioactive products. The findings also enhance our understanding of the ecological relationships between endophytic fungi.〈/p〉
Print ISSN:
0366-662X
Digitale ISSN:
1874-9356
Thema:
Biologie
