Publication Date:
2019
Description:
〈sec〉〈st〉Synopsis〈/st〉〈p〉〈textbox textbox-type="graphic"〉〈p〉〈inline-fig〉〈/inline-fig〉〈/p〉〈/textbox〉〈/p〉
〈p〉The Down syndrome critical region 1 (DSCR1) protein, which is upregulated in Down syndrome, plays a significant role in adult hippocampal neurogenesis. This work provides evidence that DSCR1 acts upstream of two epigenetic factors, TET1 and 〈i〉miRNA-124〈/i〉, and that interplay between DNA methylation and miRNA pathways regulate adult neurogenesis and learning and memory.〈/p〉
〈p〉 〈l type="unord"〉〈li〉〈p〉〈i〉DSCR〈/i〉1 knockout and transgenic brains show defective hippocampal adult neurogenesis.〈/p〉〈/li〉
〈li〉〈p〉DSCR1 binds to the introns of 〈i〉TET1〈/i〉, which regulates 〈i〉TET1〈/i〉mRNA splicing and its expression.〈/p〉〈/li〉
〈li〉〈p〉TET1 regulates DNA methylation in the promoter of 〈i〉miRNA-124〈/i〉, which subsequently alters 〈i〉miR-124〈/i〉 expression.〈/p〉〈/li〉
〈li〉〈p〉Defects both in adult neurogenesis and learning & memory manifested in Ts65Dn are prevented by reducing triplicate DSCR1 to duplicate in Ts65Dn.〈/p〉〈/li〉〈/l〉 〈/p〉〈/sec〉
Print ISSN:
0261-4189
Electronic ISSN:
1460-2075
Topics:
Biology
,
Medicine
