Publication Date:
2019
Description:
〈p〉Publication date: Available online 23 May 2019〈/p〉
〈p〉〈b〉Source:〈/b〉 Trends in Biotechnology〈/p〉
〈p〉Author(s): Arianna Oddo, Bo Peng, Ziqiu Tong, Yingkai Wei, Wing Yin Tong, Helmut Thissen, Nicolas Hans Voelcker〈/p〉
〈div xml:lang="en"〉〈div〉〈p〉Therapeutic options for neurological disorders currently remain limited. The intrinsic complexity of the brain architecture prevents potential therapeutics from reaching their cerebral target, thus limiting their efficacy. Recent advances in microfluidic technology and organ-on-chip systems have enabled the development of a new generation of 〈em〉in vitro〈/em〉 platforms that can recapitulate complex 〈em〉in vivo〈/em〉 microenvironments and physiological responses. In this context, microfluidic-based 〈em〉in vitro〈/em〉 models of the blood–brain barrier (BBB) are of particular interest as they provide an innovative approach for conducting research related to the brain, including modeling of neurodegenerative diseases and high-throughput drug screening. Here, we present the most recent advances in BBB-on-chip devices and examine validation steps that will strengthen their future applications.〈/p〉〈/div〉〈/div〉
Print ISSN:
0167-7799
Electronic ISSN:
1879-3096
Topics:
Biology
,
Process Engineering, Biotechnology, Nutrition Technology
