Publication Date:
2019
Description:
〈sec〉〈st〉Synopsis〈/st〉〈p〉〈textbox textbox-type="graphic"〉〈p〉〈inline-fig〉〈/inline-fig〉〈/p〉〈/textbox〉〈/p〉
〈p〉The flagellar motor is one of the most complex machines in bacteria and its assembly requires the spatial and temporal synchronization of hundreds of proteins. Electron cryo-tomography reveals that Gammaproteobacteria disassemble their flagella in response to limited nutrient sources in the environment, whereas flagellar assembly is regulated via an "inside-out" pathway.〈/p〉
〈p〉 〈l type="unord"〉〈li〉〈p〉〈i〉Legionella pneumophila〈/i〉,〈i〉 Pseudomonas aeruginosa〈/i〉 and 〈i〉Shewenella oneidensis〈/i〉 disassemble their flagella when nutrients are scarce.〈/p〉〈/li〉
〈li〉〈p〉Flagellar disassembly leaves outer-membrane-associated sub-complexes without generating pores in the outer membrane.〈/p〉〈/li〉
〈li〉〈p〉The assembly of the flagellar motor in these pathogens follows the "inside-out" pathway previously described for 〈i〉Salmonella〈/i〉 and 〈i〉E. coli〈/i〉.〈/p〉〈/li〉〈/l〉 〈/p〉〈/sec〉
Print ISSN:
0261-4189
Electronic ISSN:
1460-2075
Topics:
Biology
,
Medicine