Publication Date:
2019
Description:
〈sec〉〈st〉Synopsis〈/st〉〈p〉〈textbox textbox-type="graphic"〉〈p〉〈inline-fig〉〈/inline-fig〉〈/p〉〈/textbox〉〈/p〉
〈p〉-Secretase mediated cleavage of APP defines the length of Aβ peptides. Alzheimer's disease causing mutations destabilize -secretase – APP interactions and thus promote the production of longer, amyloidogenic Aβs. Here, we investigated the molecular strategies securing -secretase – APP interactions.〈/p〉
〈p〉 〈l type="unord"〉〈li〉〈p〉NCT ectodomain establishes a direct, short distance interaction with APP ectodomain.〈/p〉〈/li〉
〈li〉〈p〉NCT-APP interface influences the stability of -secretase – APP interactions and thereby modulates Aβ length.〈/p〉〈/li〉
〈li〉〈p〉NCT ectodomain influences the response towards compounds modulating Aβ length.〈/p〉〈/li〉
〈li〉〈p〉The data suggest a potential link between single nucleotide variants in 〈i〉NCSTN〈/i〉 and AD risk.〈/p〉〈/li〉〈/l〉 〈/p〉〈/sec〉
Print ISSN:
0261-4189
Electronic ISSN:
1460-2075
Topics:
Biology
,
Medicine