Publication Date:
2019
Description:
〈p〉Publication date: Available online 14 March 2019〈/p〉
〈p〉〈b〉Source:〈/b〉 Trends in Biotechnology〈/p〉
〈p〉Author(s): Saketh Gudipati, Ke Zhang, Jessica L. Rouge〈/p〉
〈div〉〈p〉Nanoscale structures of therapeutic nucleic acids have shown enormous potential to help clinicians realize the promise of personaliz ed medicine using gene-specific treatments. With the advent of better sequencing through bioinformatic approaches and advancements in nucleic acid stabilization chemistries, the field of synthetic nucleic acid nanomaterials has advanced tremendously. This review focuses on an emerging strategy geared at gene silencing without the use of traditional polycation-based transfection agents and discusses how such nanostructures are being chemically tailored to navigate biological systems to improve their circulation time and biodistribution. We also address important challenges moving forward, including quantification of delivery and the multiplexing of sequences for regulating gene networks – a goal well suited for this unique class of materials.〈/p〉〈/div〉
Print ISSN:
0167-7799
Electronic ISSN:
1879-3096
Topics:
Biology
,
Process Engineering, Biotechnology, Nutrition Technology
