Publication Date:
2019
Description:
〈sec〉〈st〉Synopsis〈/st〉〈p〉〈textbox textbox-type="graphic"〉〈p〉〈inline-fig〉〈/inline-fig〉〈/p〉〈/textbox〉〈/p〉
〈p〉New conditional mouse knockout models of the BET family protein BRD4, involved in transcriptional control in hematopoietic cancers, reveal its differential requirement in normal hematopoiesis and inflammation.〈/p〉
〈p〉 〈l type="unord"〉〈li〉〈p〉BRD4 is required for development and proliferation of mouse hematopoietic stem cells.〈/p〉〈/li〉
〈li〉〈p〉BRD4 is dispensable for macrophage differentiation and inflammatory response.〈/p〉〈/li〉
〈li〉〈p〉BRD4 broadly occupies genic and intergenic regions of transcribed genes in both unstimulated and LPS-stimulated macrophages.〈/p〉〈/li〉
〈li〉〈p〉Brd4 deletion is associated with increased NF-B occupancy and increase of other BET proteins.〈/p〉〈/li〉〈/l〉 〈/p〉〈/sec〉
Print ISSN:
0261-4189
Electronic ISSN:
1460-2075
Topics:
Biology
,
Medicine