Publikationsdatum:
2018
Beschreibung:
〈sec〉〈st〉Synopsis〈/st〉〈p〉〈textbox textbox-type="graphic"〉〈p〉〈inline-fig〉〈/inline-fig〉〈/p〉〈/textbox〉〈/p〉
〈p〉The ubiquitin ligase Parkin plays a protective role in neurodegenerative disease by removing damaged mitochondria and preventing apoptosis, and by limiting the functions of pro-apoptotic effector proteins BAK and BAX. Defective control of apoptosis may contribute to the pathogenesis of early onset Parkinson's Disease caused by Parkin mutations.〈/p〉
〈p〉 〈l type="unord"〉〈li〉〈p〉Parkin activity is induced by mitochondrial damage during apoptosis.〈/p〉〈/li〉
〈li〉〈p〉Parkin mono- and di-ubiquitinates BAK at a conserved lysine in its hydrophobic groove.〈/p〉〈/li〉
〈li〉〈p〉Ubiquitination reduces BAK oligomerisation and apoptotic activity on mitochondria.〈/p〉〈/li〉
〈li〉〈p〉Parkin prevents BAX mitochondrial localisation and apoptotic activity independent of ubiquitination.〈/p〉〈/li〉
〈li〉〈p〉Certain Parkinson's Disease-associated Parkin mutants cannot ubiquitinate BAK and restrain it on mitochondria.〈/p〉〈/li〉〈/l〉 〈/p〉〈/sec〉
Print ISSN:
0261-4189
Digitale ISSN:
1460-2075
Thema:
Biologie
,
Medizin