Publication Date:
2018
Description:
〈p〉Publication date: February 2019〈/p〉
〈p〉〈b〉Source:〈/b〉 European Polymer Journal, Volume 111〈/p〉
〈p〉Author(s): Małgorzata Burek, Klaudia Kubic, Izabela Nabiałczyk, Sylwia Waśkiewicz, Ilona Wandzik〈/p〉
〈div xml:lang="en"〉
〈h5〉Abstract〈/h5〉
〈div〉〈p〉Five acid-labile diacetal crosslinkers containing disaccharide trehalose were synthesized. Effects of different substituents on aromatic ring on hydrolysis kinetics were compared using time-dependent 〈sup〉1〈/sup〉H NMR spectroscopy. A model protein (bovine serum albumin, BSA) was physically entrapped within bulk acrylamide-type hydrogels during redox-initiated free-radical polymerization. Under acidic conditions, hydrogel degradation occurred 〈em〉via〈/em〉 cleavage of diacetal crosslinks to aqueous-soluble polymeric chains and free trehalose. The relationship between hydrogel degradation and protein release at around physiological pHs was studied. It was shown that selecting an appropriate crosslinker structure and main monomer type allows the tailoring of protein release profiles.〈/p〉〈/div〉
〈/div〉
〈div xml:lang="en"〉
〈h5〉Graphical abstract〈/h5〉
〈div〉〈p〉〈figure〉〈img src="https://ars.els-cdn.com/content/image/1-s2.0-S0014305718318251-ga1.jpg" width="395" alt="Graphical abstract for this article" title=""〉〈/figure〉〈/p〉〈/div〉
〈/div〉
Print ISSN:
0014-3057
Electronic ISSN:
1873-1945
Topics:
Chemistry and Pharmacology
,
Physics
