Publication Date:
2018
Description:
〈sec〉〈st〉Synopsis〈/st〉〈p〉〈textbox textbox-type="graphic"〉〈p〉〈inline-fig〉〈/inline-fig〉〈/p〉〈/textbox〉〈/p〉
〈p〉Hematopoietic stem and progenitor cells (HSPC) exert critical roles in the cell expansion required during homeostasis and regeneration of the blood system. Here, the protein kinase C delta (PKC) is shown to limit mouse HSPC output by controlling energy metabolism and hematopoietic differentiation.〈/p〉
〈p〉 〈l type="unord"〉〈li〉〈p〉PKC restricts HSPC pool size by restraining cell cycle progression and regulating apoptosis.〈/p〉〈/li〉
〈li〉〈p〉PKC deletion enhances recovery of HSPCs in settings of BM transplant and myelosuppression.〈/p〉〈/li〉
〈li〉〈p〉PKC deletion enhances metabolic activity of HSPCs.〈/p〉〈/li〉
〈li〉〈p〉PKC sets a threshold for HSPC activation and coordinately regulates multiple targets within progenitor cell signaling.〈/p〉〈/li〉〈/l〉 〈/p〉〈/sec〉
Print ISSN:
0261-4189
Electronic ISSN:
1460-2075
Topics:
Biology
,
Medicine