Publication Date:
2018
Description:
〈p〉Publication date: January 2019〈/p〉
〈p〉〈b〉Source:〈/b〉 Phytochemistry, Volume 157〈/p〉
〈p〉Author(s): XingRong Peng, Lei Li, JinRun Dong, ShuangYang Lu, Jing Lu, XiaoNian Li, Lin Zhou, MingHua Qiu〈/p〉
〈div xml:lang="en"〉
〈h5〉Abstract〈/h5〉
〈div〉〈p〉Twelve previously undescribed lanostane-type triterpenoids, including three triterpenoids with a 〈em〉γ〈/em〉-lactone ring, namely applanlactones A‒C, four highly oxygenated lanostane triterpenoids, namely methyl applaniate A and applanoic acids B‒D, as well as five C21 nortriterpenoids, applanones A‒E were isolated from the fruiting bodies of 〈em〉Ganoderma applanatum〈/em〉 (Pers.) Pat.〈em〉.〈/em〉 Their structures were elucidated by 1D, 2D NMR and MS spectra, as well as X-ray crystallographic analyses. Meanwhile, applanlactone A, methyl applaniate A and applanoic acid B showed inhibitory effects for the proliferation of hepatic stellate cells (HSCs) induced by transforming growth factor-〈em〉β〈/em〉1 (TGF-〈em〉β〈/em〉1) 〈em〉in vitro〈/em〉.〈/p〉〈/div〉
〈/div〉
〈h5〉Graphical abstract〈/h5〉
〈div〉〈p〉Three polyoxygenated lanostane triterpenoids isolated from the fruiting bodies of 〈em〉Ganoderma applanatum〈/em〉 showed anti-liver fibrosis activities.〈figure〉〈img src="https://ars.els-cdn.com/content/image/1-s2.0-S0031942218303352-fx1.jpg" width="369" alt="Image 1" title="Image 1"〉〈/figure〉〈/p〉〈/div〉
Print ISSN:
0031-9422
Electronic ISSN:
1873-3700
Topics:
Biology
,
Chemistry and Pharmacology
