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    Design, synthesis and evaluation of novel 2,2-dimethyl-2,3-dihydroquinolin-4(1H)-one based chalcones as cytotoxic agents (2018)
    Elsevier
    In: Heliyon
    Details
    Publication Date: 2018
    Description: 〈p〉Publication date: September 2018〈/p〉 〈p〉〈b〉Source:〈/b〉 Heliyon, Volume 4, Issue 9〈/p〉 〈p〉Author(s): Julie Jean, David S. Farrell, Angela M. Farrelly, Sinead Toomey, James W. Barlow〈/p〉 〈div xml:lang="en"〉 〈h5〉Abstract〈/h5〉 〈div〉〈p〉We designed and synthesised a series of novel chalcones, incorporating the heterocyclic framework of 2,2-dimethyl-2,3-dihydro-4(1H)-quinolinone, which was prepared via Sonogashira coupling of a substituted orthoaniline under aqueous conditions using Pd catalysis followed by acid-mediated cyclisation. The compounds were screened against the NCI-N87 and DLD-1 cancer cell lines, with most compounds showing low micromolar cytotoxic activity.〈/p〉〈/div〉 〈/div〉
    Electronic ISSN: 2405-8440
    Topics: Natural Sciences in General
    Published by Elsevier
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