ALBERT

Description: 〈p〉Publication date: 20 December 2018〈/p〉 〈p〉〈b〉Source:〈/b〉 Colloids and Surfaces A: Physicochemical and Engineering Aspects, Volume 559〈/p〉 〈p〉Author(s): Chao Han, Ning Cai, Vincent Chan, Mingming Liu, Xiaojuan Feng, Faquan Yu〈/p〉 〈h5〉Abstract〈/h5〉 〈div〉〈p〉A facile strategy to incorporate dual sustained-release system in electrospun poly(lactic acid) (PLA) nanofibers is proposed for emerging applications in advanced drug delivery. Firstly, a model antimicrobial therapeutics, tetracycline hydrochloride (TCH) was blended with Fe〈sub〉3〈/sub〉O〈sub〉4〈/sub〉-COOH nanoparticles 〈em〉via〈/em〉 electrostatic interaction to form novel composite nanoparticles. Then the influence of Fe〈sub〉3〈/sub〉O〈sub〉4〈/sub〉-COOH or TCH/Fe〈sub〉3〈/sub〉O〈sub〉4〈/sub〉-COOH nanoparticle incorporation on the morphology, porosity and hydrophilicity of electrospun PLA nanofiber membranes were elucidated. By studying drug release profiles, the newly designed TCH/Fe〈sub〉3〈/sub〉O〈sub〉4〈/sub〉-COOH/PLA nanofibrous membrane exhibited an obvious transition of drug release mechanisms from zero order release kinetics within the initial 6 days to modulated release beyond 6 days (until 14 days) in PBS. In contrast, TCH/Fe〈sub〉3〈/sub〉O〈sub〉4〈/sub〉-COOH and TCH/PLA nanofibrous membrane display single mechanism of burst like release within 3.5 days and 2.5 days, respectively. The Young's modulus, tensile strength and toughness of TCH/Fe〈sub〉3〈/sub〉O〈sub〉4〈/sub〉-COOH/PLA nanofibers are increased by 191%, 150% and 223%, respectively, compared with those of plain PLA electrospun nanofibers. Most importantly, TCH/Fe〈sub〉3〈/sub〉O〈sub〉4〈/sub〉-COOH/PLA nanofibrous membrane exhibited significantly stronger antibacterial activities against 〈em〉E. coli〈/em〉 and 〈em〉S. aureus〈/em〉 compared to TCH/Fe〈sub〉3〈/sub〉O〈sub〉4〈/sub〉-COOH and TCH/PLA nanofibrous membrane. The improved mechanical performance and sustained drug release behavior on TCH/Fe〈sub〉3〈/sub〉O〈sub〉4〈/sub〉-COOH/PLA pave the way for the emerging applications in drug delivery and tissue engineering.〈/p〉〈/div〉 〈h5〉Graphical abstract〈/h5〉 〈div〉〈p〉〈figure〉〈img src="https://ars.els-cdn.com/content/image/1-s2.0-S0927775718310033-ga1.jpg" width="500" alt="Graphical abstract for this article" title=""〉〈/figure〉〈/p〉〈/div〉