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Normalizing vessels through oncogene inhibition [Letters (Online Only)] (2012)

Goel, S., Fukumura, D., Jain, R. K.

National Academy of Sciences

In: PNAS - Proceedings of the National Academy of Sciences

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Publication Date: 2012-05-16

Description: The work by Bottos et al. (1) reported the effects of the proto-oncogene BRAF inhibition on the vasculature of solid tumors harboring the BRAFV600E oncogenic mutation. In particular, the work by Bottos et al. (1) showed that suppression of BRAF signaling in these tumors diminished tumor cell expression of several proangiogenic factors downstream of BRAF, which in turn stabilized vessel architecture, improved perfusion, and abrogated hypoxia. These findings are supportive of vascular normalization, a hypothesis that we first proposed in 2001 and then elaborated on in 2005 (2). Through restoration of the balance between proangiogenic and antiangiogenic factors in a...

Keywords: Letters

Print ISSN: 0027-8424

Electronic ISSN: 1091-6490

Topics: Biology , Medicine , Natural Sciences in General

Published by National Academy of Sciences

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