Publication Date:
2011-11-15
Description:
Methyl epiboxidine- N -carboxylate ( 8 ) was synthesized from 7 under reductive Heck conditions ( Scheme 2 ). The C C coupling of the new epiboxidine analog 9 with aryl and heteroaryl halides gave by hydroarylation C -aryl, N -(3-methylisoxazol-5-yl)-substituted tricyclic imides 10a – 10f ( Table ). The [3+2] cycloaddition of 9 with nitrile oxides yielded the bridged dihydroisoxazole derivatives 11a – 11d with potential biological activity ( Scheme 4 ).
Print ISSN:
0018-019X
Electronic ISSN:
1522-2675
Topics:
Chemistry and Pharmacology