Publication Date:
2011-07-20
Description:
The recent study of Graczyk et al. (1) reported a role for casein kinase II (CK2) phosphorylation of Maf1 during the reactivation of RNA polymerase III (Pol III) transcription that occurs as cells transition from repressive to favorable growth conditions. This is a potentially important finding. However, the preceding conclusion remains in question because of two concerns that allow alternative explanations for the data.Using the differential mobility of Maf1 in one-dimensional SDS gels, Graczyk et al. (1) reported changes in Maf1 phosphorylation upon conditional or pharmacological inhibition of CK2. However, prior work has established that these same changes in the...
Keywords:
Letters
Print ISSN:
0027-8424
Electronic ISSN:
1091-6490
Topics:
Biology
,
Medicine
,
Natural Sciences in General