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    Towards Self-Replicating Chemical Systems Based on Cytidylic and Guanylic Acids (1999)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: This project was aimed towards a better understanding of template-directed reactions and, based on this, towards the development of efficient non-enzymatic RNA replicating systems. These systems could serve as models for the prebiotic synthesis of an RNA world. The major objectives of this project are: (a) To elucidate the mechanistic aspects of template-directed (TD) chemistry and (b) to identify active boundary regions, or conditions, environmental and other, that favor "organized chemistry" and stereo-selective polymerization of nucleotides. "Organized chemistry" may lead to enhanced polymerization efficiency which in turn is expected to facilitate the road towards a self-replicating chemical system based on all four nucleic acid bases.
    Keywords: Nonmetallic Materials
    Format: application/pdf
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