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    Ultrastructural changes in rat lung during long-term exposure to oxygen. (1971)
    In:  Other Sources
    Details
    Publication Date: 2011-08-16
    Description: The pathogenesis of oxygen toxicity in the lung of rats was studied by electron microscopy. The following long-term effects were established: (1) a progressive destruction of the blood-air barrier beginning with the endothelial cell layer; (2) a profuse edema in the interstitial spaces in the pleural space in the alveoli and in the cytoplasm and organelles; (3) a continuing increase in the quantity and complexity of the alveolar exudate; (4) gradual hemolysis of red blood cells; and (5) eventual subsiding of the interstitial edema in surviving rats with a concomitant development of emphysema.
    Keywords: BIOSCIENCES
    Type: Experimental Medicine and Surgery; 29; 1971
    Format: text
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