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Termination of DNA replication of bacterial and plasmid chromosomes (1999)

Bussiere, Dirksen E. ; Bastia, Deepak

Oxford BSL : Blackwell Science Ltd

Molecular microbiology 31 (1999), S. 0

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ISSN: 1365-2958

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Biology , Medicine

Notes: Sequence-specific replication termini occur in many bacterial and plasmid chromosomes and consist of two components: a cis-acting ter site and a trans-acting replication terminator protein. The interaction of a terminator protein with the ter site creates a protein–DNA complex that arrests replication forks in a polar fashion by antagonizing the action of the replicative helicase (thereby exhibiting a contrahelicase activity). Terminator proteins also arrest RNA polymerases in a polar fashion. Passage of an RNA transcript through a terminus from the non-blocking direction abrogates replication termination function, a mechanism that is likely to be used in conditional termini or replication check points.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1046/j.1365-2958.1999.01287.x

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