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Digitale Medien

Mode of Action of Ponazuril Against Toxoplasma gondii Tachyzoites in Cell Culture (2003)

Mitchell, Sheila M. ; Zajac, Anne M. ; Davis, Wendell L. ; [weitere]

Oxford, UK : Blackwell Publishing Ltd

The @journal of eukaryotic microbiology 50 (2003), S. 0

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Details

ISSN: 1550-7408

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Biologie

Notizen: . Toxoplasma gondii is an important apicomplexan parasite of humans and other warm-blooded animals. Ponazuril is a triazine anticoccidial recently approved for use in horses in the United States. We investigated the inode of action of ponazuril against developing RH strain T. gondii tachyzoites in African green monkey kidney cells. Host cells were infected with 2.0 × 105 tachyzoites and treated with 5 μg/ml ponazuril. Cultures were fixed and examined by transmission electron microscopy 3 days after treatment. Ponazuril interfered with normal parasite division. This led to the presence of multinucleate schizonts stages. Up to six tachyzoites were observed partially budded from the surface of these schizonts. Large vacuoles developed in these schizonts and they eventually degenerated.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1111/j.1550-7408.2003.tb00689.x

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