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Mechanisms of release of ATP from vascular purinergic nerves (2003)

Chiba, S. ; Yang, X.-P.

Oxford, UK : Blackwell Science Ltd

Autonomic & autacoid pharmacology 23 (2003), S. 0

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ISSN: 1474-8673

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Chemistry and Pharmacology , Medicine

Notes: 1 The vasoconstrictor response to periarterial nerve electrical stimulation (PNS) and neurotransmission by ATP are discussed and illustrated, using canine isolated and perfused splenic arterial preparations. 2 The conditions for appearance of dominant purinergic constrictor response to PNS are discussed. 3 Modulation of the purinergic vasoconstrictor responses to PNS by several kinds of presynaptic receptor agonists and antagonists is reviewed. 4 Influences of purinergic responses to PNS by guanethidine, reserpine, tetrodotoxin (TTX) or ω-conotoxin GVIA (ωCTX) are also reviewed. 5 Effects of imipramine and removal of the endothelium are discussed. 6 Evidence is presented for selective inhibition of purinergic responses to PNS by an adequate cold storage of the vessel. 7 The roles of ATP released by PNS in isolated canine splenic arteries are proposed.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1046/j.1474-8673.2003.00283.x

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