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Use of Biological Markers in Risk Assessment1 (1994)

McMillan, Alex ; Whittemore, Alice S. ; Silvers, Abraham ; [et al.]

Oxford, UK : Blackwell Publishing Ltd

Risk analysis 14 (1994), S. 0

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ISSN: 1539-6924

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Energy, Environment Protection, Nuclear Power Engineering

Notes: Measurements of intermediate end points in the carcinogenic process may reduce uncertainty in human risk assessment from bioassay data, by identifying sources of interspecies variation and dose nonlinearity. This paper describes desirable properties of such markers: persistence, predictive power, temporal relevance, and consistency across dose rate and species. We illustrate these properties by evaluating markers for squamous cell nasal carcinoma in rodents exposed to formaldehyde. We also discuss design issues for bioassays that evaluate markers and tumors simultaneously at necropsy.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1539-6924.1994.tb00292.x

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