ISSN:
1550-7408
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Biology
Notes:
SYNOPSIS. Two blood trypanosome antigens (PR and AG) have been isolated from the serum of infected rats. These antigens are specific for each strain of trypanosome. The AG antigens, detected by agar diffusion techniques, have been extensively purified and are prctein in nature. Those isolated from two different strains differ in their heat sensitivity and in their elution patterns from calcium phosphate gel. The AG antigens are apparently not involved in the protection of mice after immunization with infected rat serum. The PR antigens, not yet detected by agar diffusion techniques, protect mice after immunization. These antigens also appear to be proteins.At least two antigens in the soluble portion of blood trypanosome homogenates are common to the “brucei” group of trypanosomes. These antigens are not involved in determining the serotype of different strains of trypanosomes. Furthermore, there are no biological properties by which the common antigen can at present be characterized.The enzyme hexokinase has also been found to be antigenically similar in both blood and culture trypanosomes. This enzyme, however, has not been detected by agar diffusion techniques. This, therefore, suggested that there are probably numerous antigens common to different strains of T. rhodesiense which have not been detected by this technique.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1550-7408.1963.tb01692.x
